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1-
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If the RBC of human were kept in 0.9% NaCl solution, what sort of change will occur to RBC?
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A -
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Cell will Burst
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B -
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Cell will shrink
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C -
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No change to RBC
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D -
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RBC will destroy
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2-
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Which of the modification in hemoglobin is the cause of sickle cell anemia?
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A -
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A mutation in the beta chain
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B -
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A deletion in the beta chain
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C -
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Replacement of the B chain by D chain
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D -
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None of the above
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3-
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Klinefelter syndrome is a manifestation of which chromosome aneuploidy?
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A -
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XXX
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B -
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XYY
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C -
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XXY
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D -
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None of these
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4-
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During sickle cell anemia which of the following takes place?
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A -
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Glutamine change to valine
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B -
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Valine change to glutamine
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C -
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Aspartic acid change to glutamic acid
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D -
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Glutamic acid change to aspartic acid
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5-
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Methotrexate is toxic to human cells because it inhibits
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A -
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formation of CTP from UTP
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B -
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reduction of H2 folate to H4 folate
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C -
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synthesis of PRPP
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D -
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None of the above
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6-
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What is the defective enzyme in the glycogen storage Von Gierke's disease?
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A -
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Phosphorylase
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B -
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Phosphofructokinase
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C -
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Glucose-6-phosphatase
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D -
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None of the above
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7-
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A deficiency of the enzyme Hypoxanthine Guanine phosphoribosyl transferase (HGPRT) may cause
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A -
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Gaucher's disease
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B -
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Ehlers-Danlos syndrome
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C -
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Lesch- Nyhan syndrome
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D -
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Kleinefelter's syndrome
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8-
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Which of the following sets belongs to a distinct class or category?
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A -
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Ribose, sucrose, glucose, fructose
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B -
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Sterols, waxes, fatty acids, amino acids.
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C -
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Oils, sterols, waxes, fats
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D -
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Nucleotide, nucleoside, nucleus, DNA
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9-
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For culturing, plasma from the adult chicken is preferred to mammalian plasma because
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A -
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it forms a clear and solid coagulum even after dilution
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B -
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it is too opaque
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C -
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it doesn't produce solid clots
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D -
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it forms a semi solid coagulum
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10-
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Toxicity due to accumulation of ammonia can be overcome
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A -
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by substituting glutamine by glutamate
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B -
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by controlled addition of glutamine at low level
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C -
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by removal of ammonia or ammonium from culture medium
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D -
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All of the above
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